研究業績

Publication

2024

Kashiwagi M, Beck G, Kanuka M, Arai Y, Tanaka K, Tatsuzawa C, Koga Y, Saito YC, Takagi M, Oishi Y, Sakaguchi M, Baba K, Ikuno M, Yamakado H, Takahashi R, Yanagisawa M, Murayama S, Sakurai T, Sakai K, Nakagawa Y, Watanabe M, Mochizuki H, Hayashi Y. A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease Cell. 2024 Sep 17:S0092-8674(24)00975-9. doi: 10.1016/j.cell.2024.08.046. Online ahead of print. PMID: 39303715

Diercks AH, Podolskaia IS, Murray TA, Mai D, Jahn AN, Amon LM, Nakagawa Y, Shimano H, Aderem A, Gold ES. Osbp family 1 integrates metabolic and inflammatory signaling in macrophages. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2406492121. doi: 10.1073/pnas.2406492121. Epub 2024 Aug 6.PMID: 39361877

Cao Y, Araki M, Nakagawa Y, Deisen L, Lundsgaard A, Kanta JM, Holm S, Johann K, Brings Jacobsen JC, Jähnert M, Schürmann A, Kiens B, Clemmensen C, Shimano H, Fritzen AM, Kleinert M.
Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis

Mol. Metab. 2024 Jul 15:101991. doi: 10.1016/j.molmet.2024.101991. Online ahead of print.PMID: 39019116

Hatano R, Lee E, Sato H, Kiuchi M, Hirahara K, Nakagawa Y, Shimano H, Nakayama T, Tanaka T, Miki T.
Hepatic ketone body regulation of renal gluconeogenesis.
Mol. Metab. 2024 Jun;84:101934. doi: 10.1016/j.molmet.2024.101934. Epub 2024 Apr 9.PMID: 38604598

Ishizawa M, Fujihara K, Yachida J, Ikeda I, Sato T, Yamada T, Kobayashi A, Tanaka S, Nakagawa Y, Matsuzaka T, Shimano H, Tashiro M, Kodama S, Kato K, Sone H.

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

J Bone Metab. 2024 Feb;31(1):21-30. doi: 10.11005/jbm.2024.31.1.21. Epub 2024 Feb 29. PMID: 38485238

FurutaY, Osaki Y, Nakagawa Y, Han SI, Araki M, Shikama A, Ohuchi N, Yamazaki D, Matsuda E, Nohara S, Mizunoe Y, Kainoh K, Suehara Y, Ohno H, Takeuchi Y, Miyamoto T, Murayama Y, Sugano Y, Iwasaki H, Hirano KI, Koseki M, Nakano S, Tokiwa H, Sekiya M, Yahagi N, Matsuzaka T, Nakamagoe K, Tomidokoro Y, Mitsui J, Tsuji S, Suzuki H, Shimano H.

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia

J Atheroscler Thromb. 2024 Mar 28. doi: 10.5551/jat.64579. Online ahead of print. PMID: 38538338

Iyoda T, Ohishi A, Wang Y, Yokoyama MS, Kazama M, Okita N, Inouye S, Nakagawa Y, Shimano H, Fukai F.
Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation
Int J Mol Sci. 2024 Feb 2;25(3):1825. doi: 10.3390/ijms25031825.

Oishi Y, Koike H, Kumagami N, Nakagawa Y, Araki M, Taketomi Y, Miki Y, Matsuda S, Matsuzaka T, Ozawa H, Shimano H, Murakami M, Manabe I.
Macrophage SREBP1 regulates skeletal muscle regeneration
Front Immunol. 2024 Jan 8;14:1251784. doi: 10.3389/fimmu.2023.1251784. eCollection 2023.

2023

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H.
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids
PNAS Nexus. 2023 Nov 8;2(11):pgad351. doi: 10.1093/pnasnexus/pgad351. eCollection 2023 Nov.PMID: 37954160

Watanabe Y, Fujisaka S, Morinaga Y, Watanabe S, Nawaz A, Hatta H, Kado T, Nishimura A, Bilal M, Aslam MR, Honda K, Nakagawa Y, Softic S, Hirabayashi K, Nakagawa T, Nagai Y, Tobe K.
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
Mol Metab. 2023 Nov;77:101797. doi: 10.1016/j.molmet.2023.101797. Epub 2023 Sep 12.

Motomura K, Matsuzaka T, Shichino S, Ogawa T, Pan H, Nakajima T, Asano Y, Okayama T, Takeuchi T, Ohno H, Han SI, Miyamoto T, Takeuchi Y, Sekiya M, Sone H, Yahagi N, Nakagawa Y, Oda T, Ueha S, Ikeo K, Ogura A, Matsushima K, Shimano H.
Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure
Diabetes. 2023 Oct 23:db230212. doi: 10.2337/db23-0212. Online ahead of print.

Kodama S, Fujihara K, Ishiguro H, Matsubayashi Y, Kitazawa M, Iwanaga M, Yamada T, Kato K, Nakagawa Y, Tanaka S, Shimano H, Sone H.J Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia
Investig Med. 2023 Apr;71(4):400-410. doi: 10.1177/10815589221149188. Epub 2023 Jan 25.PMID: 36695427

Kawano T, Kashiwagi M, Kanuka M, Chen CK, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y.
ER proteostasis regulators cell-non-autonomously control sleep.
Cell Rep. 2023 Mar 28;42(3):112267. doi: 10.1016/j.celrep.2023.112267. Epub 2023 Mar 15.PMID: 36924492

Kim JD, Kwon C, Nakamura K, Muromachi N, Mori H, Muroi SI, Yamada Y, Saito H, Nakagawa Y, Fukamizu A.
Increased angiotensin II coupled with decreased Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice
J Biol Chem. 2023 Mar;299(3):102964. doi: 10.1016/j.jbc.2023.102964. Epub 2023 Feb 2.PMID: 36736425

Istiqamah N, Matsuzaka T, Shimizu M, Motomura K, Ohno H, Hasebe S, Sharma R, Okajima Y, Matsuda E, Han SI, Mizunoe Y, Osaki Y, Aita Y, Suzuki H, Sone H, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Shimano H.
Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis
BBA Adv. 2023 Jan 22;3:100078. doi: 10.1016/j.bbadva.2023.100078. eCollection 2023.PMID: 37082255

2022

Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M, Matsuzaka T, Sone H, Shimano H.

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced NAFLD.

Am J Physiol Gastrointest Liver Physiol. 2022 2022 Dec 1;323(6):G627-G639. doi: 10.1152/ajpgi.00090.2022. Epub 2022 Oct 25.

Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi SI, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone H, Shimano H, Nakagawa Y.

Wogonin, a compound in Scutellaria baicalensis, activates ATF4–FGF21 signaling in mouse hepatocyte AML12 cells.

Nutrients 2022, 14(19), 3920; https://doi.org/10.3390/nu14193920

Kobayashi T, Kim JD, Naito A, Yanagisawa A, Jujo-Sanada T, Kasuya Y, Nakagawa Y, Sakao S, Tatsumi K, Suzuki T.

Multi‑omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin.

Int J Mol Med. 2022 May;49(5):69. doi: 10.3892/ijmm.2022.5124. Epub 2022 Mar 22.

Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H.

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

Biochim Biophys Acta Mol Basis Dis. 2022 Apr 1;1868(4):166339. doi: 10.1016/j.bbadis.2022.166339. Epub 2022 Jan 8.

Nakagawa Y, Matsuzaka T, Shimano H.

CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis.

J Diabetes Investig. 2022 Jul;13(7):1129-1131. doi: 10.1111/jdi.13766.

2021

Kodama S, Fujihara K, Horikawa C, Kitazawa M, Iwanaga M, Kato K, Watanabe K, Nakagawa Y, Matsuzaka T, Shimano H, Sone H.

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis

J Diabetes Investig. 2021 Dec 23. doi: 10.1111/jdi.13736. Online ahead of print.

Fujihara K, Nogawa S, Saito K, Horikawa Takeda Y, Cho K, Ishiguro H, Kodama S, Nakagawa Y, Matsuzaka T, Shimano H, Sone H.

Carrot consumption frequency associates with reduced BMI and obesity by the SNP intermediary rs4445711.

Nutrients. 2021 Sep 30;13(10):3478. doi: 10.3390/nu13103478.

Nakagawa Y, Han SI, Araki M, Mizunoe Y, Shimano H.

CREBH systemically regulates lipid metabolism by modulating and integrating cellular functions

Nutrients 2021 Sep 15;13(9):3204. doi: 10.3390/nu13093204.

Cho K, Ushiki T, Ishiguro H, Tamura S, Araki M, Suwabe T, Katagiri T, Ohashi R, Ajioka Y, Shimizu I, Okuda S, Masuko M, Nakagawa Y, Hirai H, Alexander WS, Shimano H, Sone H.

Altered microbiota on a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic Socs3 deficiency.

iScience 2021 Sep 11;24(10):103117. doi: 10.1016/j.isci.2021.103117.

Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida M, Umemori A, Nakagawa Y, Shimano H, Higami Y.

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle.

Exp Gerontol. 2021 Aug 17;111519. doi: 10.1016/j.exger.2021.111519.

Satou-Kobayashi Y, Kim JD, Fukamizu A, Asashima M.

Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment

Sci Rep. 2021 Jul 15;11(1):14537. doi: 10.1038/s41598-021-93524-x.

Kasuya Y, Kim JD, Hatano M, Tatsumi K, Matsuda S.

Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis.

Int J Mol Sci. 2021 Jun 3;22(11):6041. doi: 10.3390/ijms22116041.

Nakagawa Y, Kumagai K, Han S-I, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim J-D, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H.

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling.

FASEB J 2021 Jun;35(6):e21663. doi: 10.1096/fj.202002784RR.

Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H.

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.

Biochemical and Biophysical Research Communications 2021: 562:146-153

Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM, Sugiyama F.

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.

Elife. 2021;10:e50346.

Osawa T, Fujihara K, Harada Yamada M, Yamamoto M, Kitazawa M, Matsubayashi Y, Iwanaga M, Yamada T, Seida H, Kodama S, Nakagawa Y, Shimano H, Sone H.

Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus.

Journal of Investig Med. 2021;69(3):724-729.

Nakagawa Y, Wang Y, Han S-I, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H.

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition.

Cell Mol Gastroenterol Hepatol. 2021;11(4):949-971.

2020

Lim H-Y, Wang W, Nakagawa Y, Pierzchala-Koziec K

Editorial: The Endocrine Regulation of Systemic Energy Homeostasis Under Physiological and Pathological Conditions.

Frontiers in Physiology 2020 Oct 29;11:602942. doi: 10.3389/fphys.2020.602942.

Satoh A, Han S-I, Araki M, Nakagawa Y (Corresponding author), Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H.

CREBH improves diet-induced obesity, insulin resistance, and metabolic disturbances by FGF21-dependent and -independent mechanisms.

iScience 2020;23(3):100930.

Hoshino S, Kobayashi M, Tagawa R, Konno R, Abe T, Furuya K, Miura K, Wakasawa H, Okita N, Sudo Y, Mizunoe Y, Nakagawa Y, Nakamura T, Kawabe H, Higami Y.

WWP1 Knockout Mice have Exacerbated Obesity-Related Phenotype in White Adipose Tissue but Improved Whole Body Glucose Metabolism

FEBS Open Bio 2020;10(3):306-315.

Mizunoe Y, Kobayashi M, Hoshino S, Itagawa R, Hoshino A, Tagawa R, Okita N, Sudo Y, Nakagawa Y, Shimano H, Higami Y.

Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes.

Scientific Reports. 2020;10(1):634. doi: 10.1038/s41598-020-57428-6.

Kawasaki M, Kambe A, Yamamoto Y, Arulmozhiraja S, Ito S, Nakagawa Y, Tokiwa H, Nakano S, Shimano H.

Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations.

Int. J. Mol. Sci. 2020;21(1). pii: E361.

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.

Hepatocyte Elovl6 determines ceramide acyl-chain length and hepatic insulin sensitivity in mice.

Hepatology 2020;71(5):1609-1625.

2019

Ma Y, Sekiya M, Kainoh K, Matsuda T, Iwasaki H, Osaki Y, Sugano Y, Suzuki H, Takeuchi Y, Miyamoto T, Yahagi N, Nakagawa Y, Matsuzaka T, Shimano H

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.

Biochemical and Biophysical Research Communications 2020;523(2):354-360.

Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang Y, Motomura K, Shimura T, Okajima Y, Mizunoe Y, Ma Y, Saber ZM, Iwasaki H, Yatoh S, Suzuki H, Aita Y, Han SI, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Shimano H.

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.

Scientific Reports 2019;9(1):5169.

Qin R, Murakoshi N, Xu D, Tajiri K, Feng D, Stujanna EN, Yonebayashi S, Nakagawa Y, Shimano H, Nogami A, Koike A, Aonuma K, Ieda M.

Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice.

Physiol Rep. 2019 Feb;7(4):e13972.

Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Mehrazad Saber Z, Wada N, Li E, Piao X, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Miyamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.

FEBS Lett. 2019;593(4):423-432.